Abstract Group A Streptococcus (GAS) is a significant human pathogen that poses a global health concern. However. the development of a GAS vaccine has been challenging due to the multitude of diverse M-types and the risk of triggering cross-reactive immune responses. Our previous research has identified a critical role of PrsA1 and PrsA2. https://parisnaturalfoodes.shop/product-category/shark-liver-oil/